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Chemo Nausea Patch Approved 5-Day Sancuso Patch Fights Nausea From Cancer Chemotherapy None of the Viagra-treated infants developed rebound pulmonary hypertension compared to 10 of the placebo-treated infants. After more than 24 hours, all of the infants who developed rebound hypertension were given Viagra during a subsequent and successful attempt to wean them from nitric oxide. The Viagra-treated infants also spent less total time on a mechanical ventilator than the placebo-treated infants -- a little over 28 hours compared to 98 hours -- and had a considerably shorter stay in the intensive care unit (47.8 hours vs. 189 hours). "Although we expected to see an avoidance of rebound, we were not expecting to see these additional benefits," Shekerdemian said. "Any intervention that smoothes their course in the intensive-care unit would have at least a short-term positive influence on their recovery from their underlying condition." Unless there's some reason for not using Viagra, Shekerdemian said that it should be routinely used as infants are weaned from nitric oxide. "We certainly do so now in our pediatric intensive-care unit," she said. Many hospitals are already doing just that. "I think it already has become standard clinical practice, because the idea of using Viagra for this is not new," Abman said. "What's new is that this is the first study to look at it with a nice protocol in which they randomized patients and controlled in a blinded way. So it verifies what we've already been doing in clinical practice." Shekerdemian and her team are now conducting a similar study in the Royal Children's Hospital's Neonatal Intensive-Care Unit to see if Viagra can prevent rebound pulmonary hypertension in premature infants.

"Among women, cola beverages were associated with lower bone mineral density," said lead researcher Katherine Tucker, director of the Epidemiology and Dietary Assessment Program at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. There was a pretty clear dose-response, Tucker added. "Women who drink cola daily had lower bone mineral density than those who drink it only once a week," she said. "If you are worried about osteoporosis, it is probably a good idea to switch to another beverage or to limit your cola to occasional use." The report was published in the October issue of the American Journal of Clinical Nutrition. About 55 percent of Americans, mostly women, are at risk for developing osteoporosis, according to the National Osteoporosis Foundation. The drug, which became an instant blockbuster for Pfizer in 1998, works by causing blood vessels to relax - not only in the penis but in the lungs. Last year, the company won approval for the drug, also known as sildenafil, to treat a medical condition called pulmonary hypertension, or high fluid pressure in the lungs. Pulmonary hypertension is also one of the effects of exercising in oxygen-poor environments such as high altitudes. "It provides a pretty clear advantage to some people," said Annie Friedlander, the senior author of the study, which appears in the Journal of Applied Physiology. It does not help everyone. Only four of the 10 riders saw their times improve - 10 minutes, 48 seconds with Viagra compared to 15 minutes when they took a placebo. Researchers are not certain why only some volunteers responded to the drug, but they noticed that they were the ones whose times had suffered the most at high altitudes. Viagra, it seems, allowed them to make up the performance they had lost. None of the riders saw any improvement from the drug at sea level, and none reported an erection during the trials. The next step: The U.S. military plans to test Viagra, at high altitude, on about a dozen soldiers later this summer.

2 Mar, 2006 Cialis aids prostate cancer sex function ROTTERDAM, Netherlands, Oct. 2 (UPI) -- Dutch scientists say they have found a drug usually prescribed for erectile dysfunction in men increases the sexual function of prostate cancer survivors. Prostate cancer is the most commonly diagnosed cancer in men. But after treatment, some patients report trouble achieving an erection sufficient for sexual activity -- a medical condition called erectile dysfunction or ED. In the Dutch study, physicians wanted to test whether the drug Tadalafil, which sells under the brand name Cialis, would help prostate cancer survivors with ED who were treated with three-dimensional conformal radiation therapy. In what is believed the first randomized trial of its type, successful intercourse was reported in 48 percent of the survivors who took Tadalafil versus 9 percent of the men who were given placebo. There was also a reported improvement of the quality of erections in 67 percent of the patients, versus 20 percent of the placebo group. The research conducted at the Erasmus MC-Daniel den Hoed Cancer Center in Rotterdam is detailed in the International Journal of Radiation Oncology Biology Physics. http://www.sciencedaily.com/upi/index.php?feed=Science&article =UPI-1-20061002-12421600-bc-netherlands-prostatesex.xml 6 Feb, 2006 Viagra may treat 'cold hands' syndrome Study: Erectile dysfunction drug relieves symptoms of Raynaud's MEDPAGE TODAY Little Blue Pill May Put Brakes on Some Heart Disease Many men use Viagra (sildenafil) to speed up their sex lives. Now it seems that if some research pans out the little blue pill may also wind up slowing down some forms of heart disease. NEW YORK - Viagra (sildenafil) relieves the symptoms and improves the circulation of patients with Raynaud's phenomenon that does no response to conventional therapy, German investigators report. In patients with ulcers on their fingers or toes, the treatment leads to healing. Viagra, developed to treat of male erectile dysfunction, is a phosphodiesterase (PDE)-5 inhibitor that affects very small blood vessels. Studies have shown it improves circulation in other conditions, such as coronary artery disease. Raynaud's phenomenon is characterized by spasms in the small blood vessels of the hands and feet in response to cold or stress, resulting in poor circulation and pain. The disorder can also lead to ulceration or tissue death in the toes and fingers.

Most employees to pay more for health care in 2009 Fifty-nine percent of companies intend to keep down rising health care costs in 2009 by raising workers’ deductibles, copays or out-of-pocket spending limits, according to a survey by the Mercer consulting firm. On average, health care costs will rise by an estimated 5.7 percent next year for both workers and their employers. That is equal to this year’s increase and a 6.1 percent hike in 2007. The growth of health care costs has hovered at around 6 percent since 2005, according to Mercer. That’s down from the double-digit growth in previous years, but it is still moving at a faster rate than inflation or workers’ wages. The study also found that between 2003 and 2007, the average deductible for an individual grew from $250 to $400. For a family, it rose from $1,000 to $1,500. Once workers spend that out-of-pocket amount for medical care, they begin sharing costs with employers, with the company covering an average of 80 percent. The Mercer survey also found 47 percent of companies said they are encouraging enrollment in plans with lower premiums and higher deductibles. It reported that 19 percent of employers would start offering a consumer-directed health plan, which has high-deductible and employee-controlled spending accounts. Last year, 12 percent of all employers said they were “very likely” to implement such a plan by 2009. The FDA has approved Sancuso, a five-day patch that fights nausea from cancer chemotherapy. Sancuso continuously delivers a steady dose of a drug called granisetron, which blocks serotonin receptors and helps prevent nausea. Nausea is a common side effect of chemotherapy. Not all chemotherapy patients experience this side effect, but it can be life- threatening. Some patients have to prematurely stop their cancer treatment because of severe nausea and vomiting. Granisetron, delivered by injection or orally via tablets or solution, is sold under the brand name Kytril by Roche Pharmaceuticals. The Sancuso patch is from Scotland-based ProStrakan International. “A patch that can be applied before treatment, releasing medication consistently into the bloodstream over a number of days, has the potential to impact patient comfort and quality of life,” oncology nurse practitioner Barbara Rogers, CRNP, of Fox Chase Cancer Center, said in a ProStrakan news release. The transparent Sancuso patch is applied to the upper arm. The FDA approval was based on results from a Phase III clinical trial in which Sancuso was compared with once-daily oral granisetron and placebo. The patch prevented chemotherapy-induced nausea and vomiting as well as the oral product did, according to the company news release. The most important Sancuso side effect in the clinical trial was constipation. Overall, nearly 9% of patients experienced adverse reactions related to the drug, but the drug was generally well tolerated. According to the FDA, Sancuso may be used to prevent nausea and vomiting in patients receiving nausea-inducing chemotherapy regimens for up to five consecutive days. ProStrakan says Sancuso should be available to patients in December.

The erectile dysfunction drug Viagra may have found a new, potentially life-saving use in hospital pediatric intensive care units, researchers report. Australian researchers gave the drug to 15 babies with congenital heart disease who were being weaned from inhaled nitric-oxide therapy, a treatment that ICUs use to help these infants survive. The researchers found that a dose of Viagra prevented a common life-threatening complication called rebound pulmonary hypertension. They also found that it significantly reduced the amount of time the babies spent on mechanical ventilation and in the ICU. "Rebound pulmonary hypertension is a very common problem," said Dr. Steven Abman of The Children's Hospital in Denver, who was not part of the study. "This is the most rigorous study that's ever been done to demonstrate that Viagra can prevent this complication." In the study, Tucker's team collected data on more than 2,500 participants in the Framingham Osteoporosis Study, averaging just below 60 years of age. The researchers looked at bone mineral density at three different hip sites, as well as the spine. They found that in women, drinking cola was associated with lower bone mineral density at all three hip sites, regardless of age, menopause, total calcium and vitamin D intake, or smoking or drinking alcohol. Women reported drinking an average of five carbonated drinks a week, four of which were cola. Bone density among women who drank cola daily was almost 4 percent less, compared with women who didn't drink cola, Tucker said. "This is quite significant when you are talking about the density of the skeleton," she said. Cola intake was not associated with lower bone mineral density in men. The findings were similar for diet cola, but weaker for decaffeinated cola, the researchers reported. The reason for cola's effect on bone density may have to do with caffeine, Tucker said. "Caffeine is known to be associated with the risk of lower bone mineral density," she said. "But we found the same thing with decaffeinated colas." Another explanation may have to do with phosphoric acid in cola, which can cause leeching of calcium from bones to help neutralize the acid, Tucker said. One expert agrees that women should reduce the amount of cola they drink. "I would expect this finding," said Dr. Mone Zaidi, director of the Mount Sinai Bone Program at Mount Sinai School of Medicine, in New York City. "It's probably a caffeine-related problem." Women should limit their caffeine intake, Zaidi said. "Caffeine interferes with calcium absorption, which results in less bone formation," he said. This can be a problem for younger women who never develop peak bone density, Zaidi noted. "Younger women who have a lot of coke will not form bone to an extent their peers would; so, years later, in menopause, they are going to be disadvantaged," he said.

Seven-year-old girl being kept alive by Viagra Medics thought Natalie Archibald was suffering from over-excitement when she collapsed after opening her presents on Christmas Day two years ago. But she was later found to be suffering from the lung condition primary pulmonary hypertension and was referred to Great Ormond Street Hospital in London. Doctors prescribed Viagra, better known as a treatment for male impotence, and the drug has since transformed her life. Her mother Janis, from Musselburgh, near Edinburgh, said that she was surprised to learn the nature of the treatment that saved her daughter’s life. She added: “I’ve never seen her so happy. She can run, jump, skip, all the things her friends do. We have a wheelchair for her if she gets exhausted, but we’ve never had to use it, and I hope she grows out of it before we need to.” Mrs Archibald, 48, gave up her job as a legal secretary to look after Natalie after she began collapsing or turning blue on a regular basis following the first incident in 2006. She said: “It was so frustrating because I knew there was something wrong with my wee girl but no-one could find out what it was. “It got to the stage where we had almost given up trying to find out, until a doctor new to us went back into her records and carried out some more tests and diagnosed her. “Within two weeks we were down to Great Ormond Street and the drugs had started, but it was a long fight to get there.” Natalie, a rare childhood sufferer of the condition, no longer experiences fainting episodes but the condition remains potentially fatal. It is a progressive disorder that causes abnormally high blood pressure that affects arteries in the lungs. The Viagra works by opening the arteries and improving the blood flow.

Researchers Say the Drug May Help Performance at High Altitude, Help Soldiers Fight in Afghanistan As the commercials continually remind us: Viagra is all about performance. Now it turns out, that's not just referring to in the bedroom. Researchers say the drug, approved for erectile dysfunction, could eventually help some athletes train at high altitudes and soldiers fight in the mountains of Afghanistan. In a study at Stanford University, some volunteers riding stationary bicycles and breathing through masks to simulate the low oxygen conditions found at 12,700 feet, improved their times for six kilometers by an average of 39 percent after taking Viagra. The study results were published in the November issue of the American Journal of Respiratory and Critical Care Medicine. Viagra is useful for treating both erectile dysfunction and preventing rebound pulmonary hypertension because it affects pathways involved in both conditions. "Viagra enhances the body's levels of cyclic-GMP, a naturally occurring substance that relaxes arteries and reduces their pressure, which is why its primary indication is for men with erectile dysfunction," explained the study's lead researcher, Dr. Lara Shekerdemian of the Pediatric Intensive Care Unit at the Royal Children's Hospital in Melbourne. "However, cyclic-GMP is abundant in the lungs and is the molecule via which nitric oxide acts as a dilator of pulmonary arteries," Shekerdemian said. "That's why its use was explored in the setting of pulmonary hypertension in the newborn." In the study, Shekerdemian and colleagues gave a single dose of Viagra to 15 infants with congenital heart disease who were undergoing withdrawal from nitric oxide, which is used to relax pulmonary blood vessels in mechanically ventilated lungs. Another 14 infants undergoing withdrawal were given placebo.

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